Résumé de séminaire

Résumé :

Although a large variety of tools are available for the phylogenetic analysis of molecular data, human mitochondrial DNA poses specific problems, in that the database has become huge (> 20,000 entries of different pieces of information) and reflects high levels of recurrent mutations in particular stretches of the molecule that may disguise the phylogenetic content. The major challenge nowadays is (1) a better understanding of the mutational process of mitochondrial DNA, which does not seem to follow a simple evolutionary model, (2) the detection and partial correction of ubiquitous sequencing artifacts that affect most of the published data (especially in forensics), and (3) a realistic interpretation of molecular findings in a prehistoric context that would avoid naïve migrationism. These issues are addressed by focussed database searches and by employing combinatorial network methods that permit to highlight structure and pattern of the given data.

Références :

Home page : http://www.math.uni-hamburg.de/home/bandelt/

Publications en théorie des graphes : http://www.cs.columbia.edu/~sanders/graphtheory/people/Bandelt.HJ.html

CV résumé : http://www.fluxus-engineering.com/fluxe00h.htm